A strength of the BMB program is its broad combination of faculty interests and disciplines. Faculty members are drawn from many departments in the Perelman School of Medicine, from other schools in the University, and from affiliated local research institutes. The faculty are unified by the pursuit of research and training activities that align with the mission of BMB.
Charles S. Abrams, M.D. Phospholipid signaling in platelets and lymphocytes
Jessica M. Anna, Ph.D.Ultrafast multidimensional spectroscopy of natural light harvesting complexes and model systems
Yair Argon, Ph.D., Quality control of protein folding in the cell by molecular chaperones
Paul H. Axelsen, M.D., Protein misfolding diseases and pathological protein-lipid interactions; rational drug design
Tobias Baumgart, Ph.D., Biomembrane function: thermodynamics, dynamics and mechanics
Joseph A. Baur, Ph.D. Molecular mechanisms of aging and caloric restriction
Shelley L. Berger, Ph.D., Role of adaptors in regulation of transcriptional activation in yeast and humans
Ben E. Black, Ph.D., Chromosome segregation; chromatin structure; epigenetic centromere specification; hydrogen/deuterium exchange
Andres Blanco, Ph.D., Epigenetics in normal and pathological (eg. cancerous) cells
Kathleen Boesze-Battagalia, Ph.D., Degradative processes, phagocytosis and autophagy, cell homeostasis
Roberto Bonasio, Ph.D., Noncoding RNAs in chromatin biology and epigenetics.
Nancy Bonini, Ph.D, Neurodegeneration; RNA binding proteins, stress response
Donita C. Brady, Ph.D., Cancer biology, signal transduction, and metal homeostasis.
Lawrence Brass, M.D., Ph.D., Molecular basis for intracellular signaling in vascular biology
Eric J. Brown, Ph.D., Mechanisms that maintain genome stability during DNA replication
George Burslem, Ph.D. Protein Engineering, Chemical Biology, Post-translational Modifications
Theresa Busch, Ph.D., Photodynamic therapy, tumor microenvironment
Luca Busino, Ph.D, Mechanisms of protein ubiquitylation and degradation
Yi-Wei Chang Cyro-EM tomogrophy of cells
David Chenoweth, Ph.D., Development and application of synthetic methods for creating molecules that mimic or interact with biomolecules.
Sara Cherry, Ph.D., Genetic and mechanistic studies of viral-host interactions
Lewis A. Chodosh, M.D., Ph.D. Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging
Brian Y. Chow, Ph.D., Photobiology and optogenetics
Crystal Conn, Ph.D. Cancer Biology, Adaptive Stress Responses, mRNA Translation, Drug targeting, Protein Homeostasis
David Cormode, Ph.D, Medical imaging, nanoparticles, contrast agents, cardiovascular disease
Cesar de la Fuente, Ph.D, Machine Biology, Synthetic Biology, Computational Biology, Microbiology, Bioengineering.
Scott L. Diamond, Ph.D., Mechanobiology, gene transfer, blood systems biology, drug discovery, protease chemical-biology.
Roberto Dominguez, Ph.D., Actin cytoskeleton, structural biology
Gideon Dreyfuss, Ph.D., Nuclear transport, hnRNP complexes, RNA-binding proteins, spinal muscular atrophy
Roland L. Dunbrack, Jr. Ph.D., Methods and applications of protein structure prediction
Michael Farwell, MD, Developing new imaging tools, oncological applications of imaging
Feng Gai, Ph.D., Spectroscopic study of protein folding/misfolding
Alessandro Gardini, Ph.D. Understanding the role of enhancers and noncoding RNAs in transcriptional regulation in mammals.
Yale E. Goldman, M.D., Ph.D., Molecular motors and protein synthesis studied by single molecule biophysics
Mark Goulian, Ph.D., Two-component signaling, bacterial regulatory circuits
Roger Greenberg, M.D., Ph.D., Basic DNA repair mechanisms that impact cancer etiology and therapy
Kushol Gupta, Ph.D., Structural biology of large macromolecular assemblies that regulate genetic information; X-ray crystallography; small-angle cattering.
Ekaterina L. Grishchuk, Ph.D. Mechanisms that drive and control chromosome motions in mitosis
Erika Holzbaur, Ph.D., Molecular motor-driven dynamics of organelles along the cellular cytoskeleton
Xianxin Hua, Ph.D., Signaling and epigenetic regulation of cell homeostasis and tumorigenesis
Harry Ischiropoulos, Ph.D., Biological chemistry of nitric oxide; oxidative processes, protein aggregation and neurodegeneration
Paul A. Janmey, Ph.D., Cytoskeleton, biopolymer mechanics, phosphoinositides
F. Bradley Johnson, M.D., Ph.D., Telomeres, chromatin, DNA repair and their interface with cell senescence and aging.
A. Charlie Johnson, Ph.D, Nanomaterials, biosensors for disease diagnosis.
Rahul M. Kohli, M.D., Ph.D., Enzymatic basis for diversity in the immune system and pathogens; enzyme mechanisms, chemical biology, protein evolution
Daniel Kulp, Ph.D.,rational vaccine and therapeutic antibody design
Melike Lakadamyali, Ph.D. We study cytoskeleton and nuclear organization with super-resolution microscopy.
Michael Lampson, Ph.D., Chromosome segregation in mitosis and meiosis, biosensors for mitotic kinase
Mitchell Lazar, M.D., Ph.D., Nuclear receptors and the transcriptional regulation of metabolism
Edward B. Lee, MD., Ph.D., Neuropathology Alzheimer's, ALS disease
Virginia M.-Y. Lee, Ph.D., Pathobiology of Alzheimer's and Parkinson's disease
Mitchell Lewis, D.Phil. , Gene regulation; protein crystallography; structural basis of recognition
Lan Lin, Ph.D RNA modifications (a.k.a "epitranscriptomics") in human diseases
Shawn C. Little, Ph.D., Transcription bursting dynamics; single molecule measurements; cell fate specification
Kathy Fange Liu, Ph.D, The nature and mechanism of mRNA modification and its role in disease
Zhe Lu, M.D., Ph.D., Structure-function relationship of ion channels; molecular mechanisms of protein-protein interactions
Kristen W. Lynch, Ph.D., Mechanism and consequences of regulated alternative splicing
Michael S. Marks, Ph.D., Molecular mechanisms of intracellular protein transport and organelle biogenesis
Megan Matthews, Ph.D. Chemical biology and enzymology.
Mustafa Mir, Ph.D. Imaging, single molecule dynamics of gene expression
Kenji Murakami, Ph.D., Transcription initiation and regulation in eukaryote.
Ronen Marmorstein, Ph.D., Epigenetics, Protein acetylation, MAPK signaling, Metabolism, Structural Biology, Enzymology, Inhibitor Development
Vera Moiseenkova-Bell Cryo-EM, structure and function of transient receptor potential channels.
Maureen E. Murphy, Ph.D., The Murphy laboratory focuses on two tumor suppressor proteins that are commonly mutated in human cancer, p53 and p14ARF.
John I. Murray, Ph.D., Embryonic transcriptional regulation; fate specification; cell lineages; C. elegans; microscopy
E. Michael Ostap, Ph.D., Biochemistry of contractile proteins, biophysics of cell motility, and
characterization of unconventional myosins
Amish Patel, Ph.D. Predictive computational framework for characterizing biomolecular hydration, interactions and assemblies
Trevor M. Penning, Ph.D., Structure-function of aldo-keto reductases; role in steroid hormone action and chemical carcinogenesis
E. James Petersson, Ph.D., Semi-synthesis of labeled proteins to probe and control conformation
Mecky Pohlschroder Prokaryotic Cell Surface Biogenesis and Function.
Benjamin L. Prosser, Ph.D., Mechano-signaling in the heart
Ravi Radhakrishnan, Ph.D., Computational structural biology and systems biology; cell membrane mediated trafficking; targeted drug delivery; cancer signaling
Arjun Raj, Ph.D., Systems biology; developmental biology; non-coding RNA
Ravinder Reddy, Ph.D., Sodium and oxygen-17 MR methods; multiple quantum and polarization transfer MR techniques
Rhoades, Elizabeth. Functional and dysfunctional mechanisms of intrinsically disordered proteins
Heinrich Roder, Ph.D., NMR; protein folding mechanism; protein structure, dynamics and function
Harvey Rubin, M.D., Ph.D., Pathogenesis of dormancy in mycobacterium tuberculosis; biomolecular computation, and enzymology
Brian M. Salzberg, Ph.D., Multiple-site optical recording; excitation-secretion coupling; neural networks
Jeffery G. Saven, Ph.D., Theory, simulation and design of proteins and folding molecules
Mark Sellmyer, MD, Ph.D. Molecular Imaging, chemical biology, synthetic biology
Nikolaos Sgourakis, Ph.D Chemical and structural biology. Biomedical imaging, nanotechnology and supramolecular assemblies
Sydney Shaffer, MD, Ph.D. Study of single cell phenotypes in development and disease
Kim A. Sharp, Ph.D. Theory and simulation of protein and nucleic acid structure and function
Junwei Shi, Ph.D., Hepatocellular Carcinoma, epigenetic regulators, signal transduction
James Shorter, Ph.D., Regulation of beneficial or neuropathogenic prions and amyloids by protein-remodeling factors, molecular chaperones, and small molecules
Emmanuel Skordalakes, Ph.D., X-ray crystallography; telomere biology; cancer and aging
Hongjun Song, Ph.D., Neurogenesis and Epigenetic/Epitranscriptomic Mechanisms in the Nervous System
Yuanquan Song, Ph.D., Studying the formation, maintenance and function of neural circuits
David Speicher, Ph.D., Cancer proteomics; structure-function of membrane associated proteins: protein chemistry and mass spectrometry
Bin Tian, Ph.D. RNA regulated gene expression.
Paul M. Titchenell, Ph.D., Molecular mechanisms of insulin signaling and insulin resistance.
Andrew Tsourkas, Ph.D. Molecular imaging, drug delivery, nanotechnology, and biotherapeutics
Gregory D. Van Duyne, Ph.D., Structural biology; protein-protein interactions; x-ray crystallography
Sergei A. Vinogradov, Ph.D., Functional macromolecules, optical imaging probes, chemical biology, oxygen microscopy and tomography
Liling Wan, Ph.D. , Chromatin and its regulatory network, cancer biology and epigenetics.
Kai Wang, Ph.D. , Genomics and bioinformatics methods to treat rare diseases.
Felix W. Wehrli, Ph.D., MRI of biomaterials microstructure, mathematical modeling, image processing
John W. Weisel, Ph.D., Structural studies of molecular/cellular mechanisms in blood clotting and fibrinolysis
Aalim Weljie, Ph.D., Circadian, sleep, environmental and cancer metabolism via metabolomics profiling
Kathryn E. Wellen, Ph.D., Cancer cell metabolism, nutrient sensing
Walter Witschey, Ph.D. Study of cardiovascular disease using imaging and computational biology.
Xiaolu Yang, Ph.D., Molecular mechanisms of apoptosis and how they may relate to cancer and other diseases.
Kenneth S. Zaret, Ph.D., Investigating transcription factor interactions with chromatin
Zhaolan (Joe) Zhou, Ph.D., Epigenetic control of genome function in brain development and disease
© The Trustees of the University of Pennsylvania